MCB, Chemistry & NST Associate Professor Daniel Nomura and MCB & Chemistry Professor Chris Chang partner with Novartis Pharmaceuticals to identify and utilize new drug targets in the human proteome.
These new advancements in chemoproteomics could increase drug efficacy and open up new protein sites for targeted drug treatment.
Industry-minded MCB students and postdocs were enthusiastic about the opportunity to meet industry representatives and ask questions about careers in biotech at the recent MCB Industrial Affiliates Program event on April 10, 2018.
The American Association of Anatomists has honored MCB Assistant Professors Helen Bateup and Elçin Ünal with 2018 Young Investigator awards. The award recognizes early-career scientists who have made significant research contributions to biomedical science.
Sorghum plants growing at the UC Kearney Agricultural Research and Extension Center.
New research from the Department of Plant and Microbial Biology (PMB) demonstrates that exposing sorghum plants to drought conditions can shift the balance between specific types of microorganisms found within their root systems. The study, published today in PNAS, suggests that drought plays a role in restructuring the development of the early root microbiome, a finding that could help scientists develop crops that are more resistant to climate change.
PMB faculty members Devin Coleman-Derr, Peggy Lemaux, and John Taylor conducted the research at the UC Kearney Agricultural Research and Extension Center on sorghum, a cereal crop known for its drought tolerance. The following PMB graduate students and researchers also contributed to the study: Zhaobin Dong, Cheng Gao, Mary Madera, Daniel Naylor, Grady Pierroz, Tuesday Simmons, Yi Wang, and Ling Xu.
To understand the relationship between drought and sorghum’s microbiome, the research team studied a full 17-week growth cycle of the plant, taking samples weekly on the same day of the week and time. On each collection visit, samples were gathered from soil near the plants’ roots and rhizosphere—a microbe-rich soil region surrounding the root that is full of root secretions. A plant’s rhizosphere is home to a host of bacteria and other microorganisms, including fungi, which consume sugars and proteins sloughed off by root cells. Some of these compounds appear to provide a communication channel between the plant and bacteria, indicating the drought status of the plant.
After studying these samples, researchers learned that under drought conditions, the development of a plant’s microbial community is delayed and the diversity of microorganisms in the rhizosphere decreases. But once a plant’s access to water is restored, its microbiome regains its diversity of bacteria.
The discovery of this drought-induced microbiome enrichment of specific bacteria could offer a potential pathway for manipulating plant microbiomes in crops that are less drought-tolerant than sorghum. “This research represents an important step forward in our understanding of how and when plants recruit their microbial partners from the surrounding environment,” said Coleman-Derr.
The paper is the first research published from a $12.3 million Department of Energy Biological and Environmental Research-funded project, which aims to develop an in-depth understanding of drought tolerance in field-grown sorghum. The project is a collaboration between PMB scientists Coleman-Derr, Lemaux, Taylor, and John Vogel, as well as Elizabeth Purdom from UC Berkeley’s Department of Statistics, Axel Visel and Ronan O’Malley from the Joint Genome Institute, ANR Research Station directors Jeff Dahlberg and Robert Hutmacher, and Christer Jansson, a researcher at the Pacific Northwest National Laboratory.
“We hope our work will provide similar strategies in other less drought-tolerant crops that can be used to increase our capacity to provide food and animal feed in the face of challenges from climate change,” said Lemaux. “In the end, this treatment strategy might give plants one more tool to help them survive drought.”Image: Date: Monday, April 16, 2018 - 14:30 Legacy: section header item: Date: Monday, April 16, 2018 - 11:30 headline_position: Top Left headline_color_style: Normal headline_width: Long caption_color_style: Normal caption_position: Bottom Left News/Story tag(s): Research News
Gonzalez is an associate adjunct professor in the Department of Environmental Science, Policy, and Management. Gonzalez will be a lead author for a chapter about ecosystems.
IPCC is the scientific panel that produces the authoritative reports on human-caused climate change, which are then used as the standard references for scientists and policymakers. For this work, IPCC was awarded a share of the 2007 Nobel Peace Prize.
Gonzalez will serve as a lead author on the IPCC Sixth Assessment Report, Volume 2, to be published in 2021. The report will be titled “Climate Change 2021: Impacts, Adaptation, and Vulnerability.” He will be the lead author for chapter two, “Terrestrial and freshwater ecosystems and their services.”
Gonzalez is an affiliate of the UC Berkeley Institute for Parks, People, and Biodiversity and a Ph.D. alumnus of the UC Berkeley Energy and Resources Group. He is a forest ecologist and conducts applied research on climate change impacts and solutions and works with national parks, policymakers, and local people to integrate climate change science into natural resource management.
UC Berkeley professor of earth and planetary sciences William Collins, an expert in climate modeling, will also be a co-author on the report.
More on the IPCC authors can be found on the IPCC website.Image: Date: Thursday, April 12, 2018 - 11:00 Legacy: section header item: Date: Friday, April 13, 2018 - 11:00 headline_position: Top Left headline_color_style: Normal headline_width: Long caption_color_style: Normal caption_position: Bottom Left News/Story tag(s): Honors and Awards
A new study coauthored by associate professor Bree Rosenblum and graduate student Alison Byrne has found that populations of several Panamian frog species are slowly making a comeback against a deadly pathogen that can lead to extinction. Published last week in Science, the research provides evidence suggesting that the frogs have gained potent defenses in their skin against the fungus Batrachochytrium dendrobatidis (Bd), which causes a disease called chytridiomycosis and has devastated amphibian populations around the world.
- A Few Species of Frogs That Vanished May Be on the Rebound, New York Times
- Panamanian Frogs evolve to cope with a lethal skin-eating disease, Pacific Standard
- Frogs may be ‘fighting back’ against deadly pandemic, Mongabay
This semester MCB faculty, staff, and students have been working on an equity and inclusion grant we received from the PATH to Care Center on campus. Our goal is to raise awareness about positive social norms and promote an inclusive culture in biology.
KQED's 'Deep Look' web series recently featured leeches from the lab of MCB Professor David Weisblat. Learn more about how these creepy crawlers are being used in surgeries in the clip below!